| 1. | ne 25.07.202125.07. | MFK Zemplín MichalovceMIC | 4:1 |  FC DAC 1904 Dunajská StredaDAC | 90 | 0 | 0 | 56,0% | 82,6% | 23 | 0 |
| 2. | so 31.07.202131.07. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 2:0 | MFK Zemplín MichalovceMIC | 67 | 0 | 0 | 20,0% | 84,6% | 26 | 0 |
| 3. | so 07.08.202107.08. | MFK Zemplín MichalovceMIC | 1:2 |  AS TrenčínTRE | 90 | 0 | 0 | 35,3% | 71,0% | 31 | 0 |
| 4. | so 14.08.202114.08. | ŠK Slovan Bratislava SLO | 3:1 | MFK Zemplín MichalovceMIC | 90 | 1 | 0 | 55,6% | 74,3% | 35 | 0 |
| 5. | so 21.08.202121.08. | MFK Zemplín MichalovceMIC | 2:1 |  MFK Tatran Liptovský MikulášLMI | 90 | 0 | 0 | 68,0% | 89,1% | 46 | 0 |
| 6. | so 28.08.202128.08. | MFK RužomberokRUŽ | 0:0 | MFK Zemplín MichalovceMIC | 57 | 0 | 0 | 50,0% | 81,0% | 21 | |
| 7. | so 11.09.202111.09. | MFK Zemplín MichalovceMIC | 1:2 |  FC Spartak TrnavaSPA | 90 | 0 | 0 | 20,0% | 80,6% | 36 | 0 |
| 8. | so 18.09.202118.09. | MFK Zemplín MichalovceMIC | 2:1 |  FC ViOn Zlaté Moravce - VrábleZMO | 90 | 1 | 0 | 55,6% | 87,2% | 39 | 0 |
| 9. | so 25.09.202125.09. | ŠKF ORION TIP SereďSER | 0:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 38,9% | 87,2% | 39 | 0 |
| 10. | so 02.10.202102.10. | MFK Zemplín MichalovceMIC | 1:0 |  MŠK ŽilinaMŠK | 90 | 0 | 0 | 70,0% | 94,7% | 38 | 0 |
| 11. | so 16.10.202116.10. | FK SenicaSEN | 1:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 59,1% | 94,0% | 50 | |
| 13. | so 30.10.202130.10. | MFK Zemplín MichalovceMIC | 0:2 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 90 | 0 | 0 | 46,2% | 92,2% | 77 | |
| 14. | pi 05.11.202105.11. | AS TrenčínTRE | 4:2 | MFK Zemplín MichalovceMIC | 90 | 0 | 1 | 50,0% | 91,7% | 48 | 0 |
| 15. | ne 21.11.202121.11. | MFK Zemplín MichalovceMIC | 1:2 | ŠK Slovan Bratislava SLO | 90 | 0 | 0 | 39,1% | 91,3% | 46 | 0 |
| 16. | so 27.11.202127.11. | MFK Tatran Liptovský MikulášLMI | 0:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 39,1% | 86,8% | 38 | 0 |
| 17. | so 04.12.202104.12. | MFK Zemplín MichalovceMIC | 0:3 | MFK RužomberokRUŽ | 90 | 0 | 0 | 43,8% | 89,9% | 69 | 0 |
| 18. | pi 10.12.202110.12. | FC Spartak TrnavaSPA | 2:0 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 42,1% | 92,5% | 80 | 0 |
| 19. | so 18.12.202118.12. | FC ViOn Zlaté Moravce - VrábleZMO | 0:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 53,8% | 91,5% | 71 | 0 |
| 20. | pi 11.02.202211.02. | MFK Zemplín MichalovceMIC | 0:1 | ŠKF ORION TIP SereďSER | 90 | 0 | 0 | 64,7% | 87,7% | 65 | |
| 21. | so 19.02.202219.02. | MŠK ŽilinaMŠK | 2:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 55,0% | 88,6% | 44 | 0 |
| 22. | so 26.02.202226.02. | MFK Zemplín MichalovceMIC | 0:1 | FK SenicaSEN | 44 | 0 | 0 | 54,5% | 89,6% | 48 | 0 |
| Z - 1. | so 05.03.202205.03. | MFK Zemplín MichalovceMIC | 1:0 | AS TrenčínTRE | 90 | 0 | 0 | 44,4% | 76,0% | 25 | 0 |
| Z - 2. | so 12.03.202212.03. | FK SenicaSEN | 2:1 | MFK Zemplín MichalovceMIC | 76 | 0 | 0 | 47,4% | 91,2% | 34 | 0 |
| Z - 3. | so 19.03.202219.03. | MFK Zemplín MichalovceMIC | 1:0 | FC ViOn Zlaté Moravce - VrábleZMO | 90 | 0 | 0 | 41,2% | 85,4% | 48 | 0 |
| Z - 4. | so 02.04.202202.04. | MFK Zemplín MichalovceMIC | 1:0 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 90 | 0 | 1 | 38,5% | 67,6% | 37 | 0 |
| Z - 5. | pi 08.04.202208.04. | MFK Tatran Liptovský MikulášLMI | 3:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 38,9% | 83,3% | 36 | 0 |
| Z - 6. | po 18.04.202218.04. | FC ViOn Zlaté Moravce - VrábleZMO | 1:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 60,9% | 81,6% | 38 | |
| Z - 7. | so 23.04.202223.04. | MFK Zemplín MichalovceMIC | 1:0 | FK SenicaSEN | 90 | 0 | 0 | 37,5% | 81,0% | 42 | 0 |
| Z - 8. | so 30.04.202230.04. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 1:2 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 50,0% | 92,9% | 42 | 0 |
| Z - 9. | pi 13.05.202213.05. | MFK Zemplín MichalovceMIC | 1:2 | MFK Tatran Liptovský MikulášLMI | 86 | 0 | 0 | 57,1% | 89,8% | 59 | 0 |
| Z - 10. | so 21.05.202221.05. | AS TrenčínTRE | 2:2 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 60,0% | 87,1% | 31 | 0 |
