| 1. | AS TrenčínTRE | 4:0 |  FC ViOn Zlaté Moravce - VrábleZMO | pi 23.07.202123.07. | 20:00 | | Detail |
| 2. | ŠK Slovan Bratislava SLO | 2:0 | AS TrenčínTRE | so 31.07.202131.07. | 20:00 | | Detail |
| 3. | MFK Zemplín MichalovceMIC | 1:2 | AS TrenčínTRE | so 07.08.202107.08. | 18:00 | | Detail |
| 4. | AS TrenčínTRE | 1:1 |  MFK RužomberokRUŽ | pi 13.08.202113.08. | 20:00 | | Detail |
| 5. | FC DAC 1904 Dunajská StredaDAC | 1:1 | AS TrenčínTRE | ne 22.08.202122.08. | 20:00 | | Detail |
| 6. | AS TrenčínTRE | 0:0 |  ŠKF ORION TIP SereďSER | so 28.08.202128.08. | 18:00 | | Detail |
| 7. | MŠK ŽilinaMŠK | 1:3 | AS TrenčínTRE | so 11.09.202111.09. | 18:00 | | Detail |
| 8. | AS TrenčínTRE | 3:3 |  FK SenicaSEN | so 18.09.202118.09. | 18:00 | | Detail |
| 9. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 2:2 | AS TrenčínTRE | pi 24.09.202124.09. | 17:00 | | Detail |
| 10. | AS TrenčínTRE | 0:1 |  FC Spartak TrnavaSPA | ne 03.10.202103.10. | 17:00 | | Detail |
| 11. | MFK Tatran Liptovský MikulášLMI | 2:1 | AS TrenčínTRE | pi 15.10.202115.10. | 17:00 | | Detail |
| 12. | FC ViOn Zlaté Moravce - VrábleZMO | 0:1 | AS TrenčínTRE | so 23.10.202123.10. | 18:00 | | Detail |
| 13. | AS TrenčínTRE | 2:3 | ŠK Slovan Bratislava SLO | ne 31.10.202131.10. | 17:00 | | Detail |
| 14. | AS TrenčínTRE | 4:2 | MFK Zemplín MichalovceMIC | pi 05.11.202105.11. | 17:00 | | Detail |
| 15. | MFK RužomberokRUŽ | 3:0 | AS TrenčínTRE | pi 19.11.202119.11. | 17:00 | | Detail |
| 16. | AS TrenčínTRE | 0:1 | FC DAC 1904 Dunajská StredaDAC | so 27.11.202127.11. | 15:00 | | Detail |
| 17. | ŠKF ORION TIP SereďSER | 4:2 | AS TrenčínTRE | so 04.12.202104.12. | 15:00 | | Detail |
| 18. | AS TrenčínTRE | 1:3 | MŠK ŽilinaMŠK | so 11.12.202111.12. | 15:00 | | Detail |
| 19. | FK SenicaSEN | 1:0 | AS TrenčínTRE | so 18.12.202118.12. | 15:00 | | Detail |
| 20. | AS TrenčínTRE | 3:0 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | so 12.02.202212.02. | 15:00 | | Detail |
| 21. | FC Spartak TrnavaSPA | 0:0 | AS TrenčínTRE | so 19.02.202219.02. | 15:00 | | Detail |
| 22. | AS TrenčínTRE | 2:2 | MFK Tatran Liptovský MikulášLMI | so 26.02.202226.02. | 17:00 | | Detail |
| Z - 1. | MFK Zemplín MichalovceMIC | 1:0 | AS TrenčínTRE | so 05.03.202205.03. | 15:00 | | Detail |
| Z - 2. | AS TrenčínTRE | 2:0 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | pi 11.03.202211.03. | 17:00 | | Detail |
| Z - 3. | AS TrenčínTRE | 4:1 | FK SenicaSEN | so 19.03.202219.03. | 15:00 | | Detail |
| Z - 4. | MFK Tatran Liptovský MikulášLMI | 0:3 | AS TrenčínTRE | so 02.04.202202.04. | 16:00 | | Detail |
| Z - 6. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 1:1 | AS TrenčínTRE | so 16.04.202216.04. | 18:00 | | Detail |
| Z - 7. | FC ViOn Zlaté Moravce - VrábleZMO | 0:2 | AS TrenčínTRE | so 23.04.202223.04. | 18:00 | | Detail |
| Z - 5. | AS TrenčínTRE | 4:3 | FC ViOn Zlaté Moravce - VrábleZMO | ut 26.04.202226.04. | 18:00 | | Detail |
| Z - 8. | AS TrenčínTRE | 5:2 | MFK Tatran Liptovský MikulášLMI | so 30.04.202230.04. | 18:00 | | Detail |
| Z - 9. | FK SenicaSEN | 0:3 | AS TrenčínTRE | so 14.05.202214.05. | 17:00 | | Detail |
| Z - 10. | AS TrenčínTRE | 2:2 | MFK Zemplín MichalovceMIC | so 21.05.202221.05. | 17:00 | | Detail |
| - Semifinále. | MŠK ŽilinaMŠK | 0:2 | AS TrenčínTRE | ut 24.05.202224.05. | 18:00 | | Detail |
| - Finále. | FC DAC 1904 Dunajská StredaDAC | 2:1 | AS TrenčínTRE | pi 27.05.202227.05. | 20:00 | | Detail |
