| 11. | so 16.10.202116.10. | FK SenicaSEN | 1:1 |  MFK Zemplín MichalovceMIC | 8 | 0 | 0 | 66,7% | 80,0% | 5 | 0 |
| 13. | so 30.10.202130.10. | MFK Zemplín MichalovceMIC | 0:2 |  FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 30 | 0 | 0 | 66,7% | 89,5% | 19 | |
| 14. | pi 05.11.202105.11. | AS TrenčínTRE | 4:2 | MFK Zemplín MichalovceMIC | 44 | 1 | 0 | 37,5% | 90,5% | 21 | 0 |
| 15. | ne 21.11.202121.11. | MFK Zemplín MichalovceMIC | 1:2 |  ŠK Slovan Bratislava SLO | 24 | 0 | 0 | 50,0% | 90,0% | 10 | 0 |
| 18. | pi 10.12.202110.12. | FC Spartak TrnavaSPA | 2:0 | MFK Zemplín MichalovceMIC | 3 | 0 | 0 | 50,0% | 100,0% | 2 | 0 |
| 20. | pi 11.02.202211.02. | MFK Zemplín MichalovceMIC | 0:1 |  ŠKF ORION TIP SereďSER | 22 | 0 | 0 | 75,0% | 85,7% | 14 | 0 |
| 21. | so 19.02.202219.02. | MŠK ŽilinaMŠK | 2:1 | MFK Zemplín MichalovceMIC | 27 | 0 | 0 | 66,7% | 85,7% | 14 | 0 |
| 22. | so 26.02.202226.02. | MFK Zemplín MichalovceMIC | 0:1 | FK SenicaSEN | 46 | 0 | 0 | 12,5% | 71,4% | 14 | 0 |
| Z - 2. | so 12.03.202212.03. | FK SenicaSEN | 2:1 | MFK Zemplín MichalovceMIC | 14 | 0 | 0 | 42,9% | 85,7% | 7 | 0 |
| Z - 5. | pi 08.04.202208.04. | MFK Tatran Liptovský MikulášLMI | 3:1 | MFK Zemplín MichalovceMIC | 8 | 0 | 0 | 0,0% | 75,0% | 4 | 0 |
| Z - 7. | so 23.04.202223.04. | MFK Zemplín MichalovceMIC | 1:0 | FK SenicaSEN | 29 | 0 | 0 | 76,9% | 92,3% | 26 | 0 |
| Z - 8. | so 30.04.202230.04. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 1:2 | MFK Zemplín MichalovceMIC | 64 | 0 | 0 | 35,7% | 80,8% | 26 | 0 |
| Z - 9. | pi 13.05.202213.05. | MFK Zemplín MichalovceMIC | 1:2 | MFK Tatran Liptovský MikulášLMI | 62 | 0 | 0 | 45,5% | 85,2% | 27 | 0 |
