| 16. | ne 28.11.202128.11. | FC Spartak TrnavaSPA | 0:3 |  MFK RužomberokRUŽ | 8 | 0 | 0 | 0,0% | 77,8% | 9 | 0 |
| 17. | ne 05.12.202105.12. | MŠK ŽilinaMŠK | 0:1 | FC Spartak TrnavaSPA | 7 | 0 | 0 | 100,0% | 100,0% | 4 | 0 |
| 18. | pi 10.12.202110.12. | FC Spartak TrnavaSPA | 2:0 |  MFK Zemplín MichalovceMIC | 11 | 0 | 0 | 25,0% | 57,1% | 7 | 0 |
| 19. | so 18.12.202118.12. | ŠKF ORION TIP SereďSER | 0:1 | FC Spartak TrnavaSPA | 21 | 0 | 0 | 80,0% | 90,0% | 10 | 0 |
| 20. | ne 13.02.202213.02. | FC Spartak TrnavaSPA | 1:1 |  FC DAC 1904 Dunajská StredaDAC | 10 | 0 | 0 | 75,0% | 75,0% | 4 | 0 |
| 21. | so 19.02.202219.02. | FC Spartak TrnavaSPA | 0:0 |  AS TrenčínTRE | 12 | 0 | 0 | 42,9% | 50,0% | 4 | 0 |
| T6 - 2. | ne 13.03.202213.03. | FC DAC 1904 Dunajská StredaDAC | 1:1 | FC Spartak TrnavaSPA | 44 | 0 | 0 | 60,0% | 72,4% | 29 | 0 |
| T6 - 3. | ne 20.03.202220.03. | MFK RužomberokRUŽ | 0:0 | FC Spartak TrnavaSPA | 69 | 0 | 0 | 57,1% | 67,9% | 28 | 0 |
| T6 - 4. | ne 03.04.202203.04. | FC Spartak TrnavaSPA | 0:1 |  ŠK Slovan Bratislava SLO | 82 | 0 | 0 | 50,0% | 80,0% | 35 | 0 |
| T6 - 6. | ne 17.04.202217.04. | ŠKF ORION TIP SereďSER | 0:2 | FC Spartak TrnavaSPA | 41 | 0 | 0 | 33,3% | 83,3% | 12 | 0 |
| T6 - 7. | ne 24.04.202224.04. | FC Spartak TrnavaSPA | 0:0 | MFK RužomberokRUŽ | 20 | 0 | 0 | 50,0% | 100,0% | 9 | 0 |
| T6 - 8. | ne 01.05.202201.05. | ŠK Slovan Bratislava SLO | 1:0 | FC Spartak TrnavaSPA | 19 | 0 | 0 | 0,0% | 81,8% | 11 | 0 |
