| 1. | ne 25.07.202125.07. | MFK Zemplín MichalovceMIC | 4:1 |  FC DAC 1904 Dunajská StredaDAC | 90 | 0 | 0 | 93,8% | 65,2% | 23 | 0 |
| 2. | so 31.07.202131.07. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 2:0 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 75,0% | 80,6% | 62 | 0 |
| 3. | so 07.08.202107.08. | MFK Zemplín MichalovceMIC | 1:2 |  AS TrenčínTRE | 90 | 0 | 0 | 80,0% | 64,7% | 34 | 0 |
| 4. | so 14.08.202114.08. | ŠK Slovan Bratislava SLO | 3:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 76,9% | 81,1% | 37 | |
| 7. | so 11.09.202111.09. | MFK Zemplín MichalovceMIC | 1:2 |  FC Spartak TrnavaSPA | 90 | 1 | 0 | 75,0% | 66,7% | 54 | 0 |
| 8. | so 18.09.202118.09. | MFK Zemplín MichalovceMIC | 2:1 |  FC ViOn Zlaté Moravce - VrábleZMO | 90 | 0 | 1 | 63,2% | 76,6% | 47 | |
| 9. | so 25.09.202125.09. | ŠKF ORION TIP SereďSER | 0:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 1 | 53,3% | 58,1% | 31 | |
| 10. | so 02.10.202102.10. | MFK Zemplín MichalovceMIC | 1:0 |  MŠK ŽilinaMŠK | 90 | 0 | 0 | 69,2% | 71,0% | 31 | |
| 11. | so 16.10.202116.10. | FK SenicaSEN | 1:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 55,6% | 81,1% | 37 | |
| 13. | so 30.10.202130.10. | MFK Zemplín MichalovceMIC | 0:2 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 90 | 0 | 0 | 61,1% | 81,7% | 71 | 0 |
| 14. | pi 05.11.202105.11. | AS TrenčínTRE | 4:2 | MFK Zemplín MichalovceMIC | 46 | 0 | 0 | 100,0% | 86,7% | 15 | 0 |
| 16. | so 27.11.202127.11. | MFK Tatran Liptovský MikulášLMI | 0:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 65,2% | 80,0% | 45 | 0 |
| 17. | so 04.12.202104.12. | MFK Zemplín MichalovceMIC | 0:3 |  MFK RužomberokRUŽ | 84 | 0 | 0 | 60,0% | 80,0% | 50 | 0 |
| 19. | so 18.12.202118.12. | FC ViOn Zlaté Moravce - VrábleZMO | 0:1 | MFK Zemplín MichalovceMIC | 2 | 0 | 0 | 100,0% | 100,0% | 1 | 0 |
| 21. | so 19.02.202219.02. | MŠK ŽilinaMŠK | 2:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 91,7% | 78,6% | 42 | 0 |
| 22. | so 26.02.202226.02. | MFK Zemplín MichalovceMIC | 0:1 | FK SenicaSEN | 46 | 0 | 0 | 57,1% | 69,2% | 26 | 0 |
| Z - 1. | so 05.03.202205.03. | MFK Zemplín MichalovceMIC | 1:0 | AS TrenčínTRE | 5 | 0 | 0 | 50,0% | 0,0% | 0 | 0 |
| Z - 3. | so 19.03.202219.03. | MFK Zemplín MichalovceMIC | 1:0 | FC ViOn Zlaté Moravce - VrábleZMO | 1 | 0 | 0 | 0,0% | 0,0% | 1 | 0 |
| Z - 4. | so 02.04.202202.04. | MFK Zemplín MichalovceMIC | 1:0 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 38 | 0 | 0 | 33,3% | 80,0% | 20 | 0 |
| Z - 5. | pi 08.04.202208.04. | MFK Tatran Liptovský MikulášLMI | 3:1 | MFK Zemplín MichalovceMIC | 82 | 0 | 1 | 62,1% | 73,3% | 30 | 0 |
| Z - 6. | po 18.04.202218.04. | FC ViOn Zlaté Moravce - VrábleZMO | 1:1 | MFK Zemplín MichalovceMIC | 18 | 0 | 0 | 33,3% | 70,0% | 10 | 0 |
| Z - 7. | so 23.04.202223.04. | MFK Zemplín MichalovceMIC | 1:0 | FK SenicaSEN | 90 | 0 | 0 | 75,0% | 94,0% | 67 | 0 |
