| 19. | ne 14.02.202114.02. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 1:1 |  MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 48,1% | 92,9% | 28 | 0 |
| 20. | so 20.02.202120.02. | MFK Zemplín MichalovceMIC | 0:2 |  ŠKF ORION TIP SereďSER | 83 | 0 | 0 | 48,0% | 77,8% | 27 | 0 |
| 21. | so 27.02.202127.02. | FC DAC 1904 Dunajská StredaDAC | 2:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 50,0% | 81,8% | 22 | 0 |
| 22. | so 06.03.202106.03. | MFK Zemplín MichalovceMIC | 1:0 |  FC NitraNIT | 90 | 0 | 0 | 46,7% | 86,1% | 36 | 0 |
| Z - 2. | so 20.03.202120.03. | MFK RužomberokRUŽ | 2:0 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 72,7% | 90,5% | 42 | 0 |
| Z - 3. | so 03.04.202103.04. | MFK Zemplín MichalovceMIC | 1:0 |  FK SenicaSEN | 90 | 0 | 0 | 40,0% | 63,2% | 38 | |
| Z - 4. | so 10.04.202110.04. | MFK Zemplín MichalovceMIC | 1:2 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 90 | 0 | 0 | 41,7% | 95,3% | 43 | |
| Z - 5. | so 17.04.202117.04. | ŠKF ORION TIP SereďSER | 2:0 | MFK Zemplín MichalovceMIC | 76 | 0 | 0 | 80,0% | 91,2% | 34 | |
| Z - 6. | so 24.04.202124.04. | FK SenicaSEN | 1:1 | MFK Zemplín MichalovceMIC | 85 | 0 | 0 | 33,3% | 64,7% | 17 | 0 |
| Z - 7. | so 01.05.202101.05. | MFK Zemplín MichalovceMIC | 2:1 | MFK RužomberokRUŽ | 46 | 0 | 0 | 22,2% | 90,0% | 10 | 0 |
| Z - 8. | so 08.05.202108.05. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 0:0 | MFK Zemplín MichalovceMIC | 28 | 0 | 0 | 100,0% | 50,0% | 6 | 0 |
| Z - 9. | so 15.05.202115.05. | MFK Zemplín MichalovceMIC | 2:2 | ŠKF ORION TIP SereďSER | 90 | 1 | 0 | 47,4% | 76,9% | 26 | 0 |
| Z - 10. | so 22.05.202122.05. | FC NitraNIT | 0:4 | MFK Zemplín MichalovceMIC | 51 | 1 | 1 | 53,8% | 75,0% | 12 | |
