| 2. | pi 30.07.202130.07. | ŠKF ORION TIP SereďSER | 2:3 |  MFK RužomberokRUŽ | 44 | 0 | 0 | 47,6% | 50,0% | 12 | 0 |
| 4. | pi 13.08.202113.08. | AS TrenčínTRE | 1:1 | MFK RužomberokRUŽ | 5 | 0 | 0 | 42,9% | 33,3% | 3 | 0 |
| 5. | so 21.08.202121.08. | MFK RužomberokRUŽ | 0:0 |  FC Spartak TrnavaSPA | 17 | 0 | 0 | 36,4% | 62,5% | 8 | 0 |
| 6. | so 28.08.202128.08. | MFK RužomberokRUŽ | 0:0 |  MFK Zemplín MichalovceMIC | 22 | 0 | 0 | 60,0% | 80,0% | 10 | 0 |
| 7. | pi 10.09.202110.09. | FC ViOn Zlaté Moravce - VrábleZMO | 2:2 | MFK RužomberokRUŽ | 14 | 0 | 0 | 60,0% | 71,4% | 7 | 0 |
| 12. | so 23.10.202123.10. | FK SenicaSEN | 0:2 | MFK RužomberokRUŽ | 72 | 0 | 0 | 25,0% | 73,9% | 23 | 0 |
| 13. | so 30.10.202130.10. | MFK RužomberokRUŽ | 3:1 | ŠKF ORION TIP SereďSER | 71 | 2 | 0 | 47,6% | 56,3% | 16 | 0 |
| 14. | ne 07.11.202107.11. | ŠK Slovan Bratislava SLO | 1:0 | MFK RužomberokRUŽ | 28 | 0 | 0 | 40,0% | 80,0% | 5 | 0 |
| 15. | pi 19.11.202119.11. | MFK RužomberokRUŽ | 3:0 | AS TrenčínTRE | 75 | 0 | 1 | 68,4% | 81,8% | 22 | 0 |
| 16. | ne 28.11.202128.11. | FC Spartak TrnavaSPA | 0:3 | MFK RužomberokRUŽ | 24 | 0 | 0 | 50,0% | 100,0% | 8 | 0 |
| 17. | so 04.12.202104.12. | MFK Zemplín MichalovceMIC | 0:3 | MFK RužomberokRUŽ | 90 | 0 | 0 | 36,7% | 70,0% | 30 | 0 |
| 18. | so 11.12.202111.12. | MFK RužomberokRUŽ | 1:1 | FC ViOn Zlaté Moravce - VrábleZMO | 90 | 0 | 0 | 46,4% | 71,4% | 42 | 0 |
| 19. | pi 17.12.202117.12. | FC DAC 1904 Dunajská StredaDAC | 0:0 | MFK RužomberokRUŽ | 74 | 0 | 0 | 45,0% | 64,0% | 25 | 0 |
| 20. | po 14.02.202214.02. | MFK RužomberokRUŽ | 5:1 |  MŠK ŽilinaŽIL | 23 | 1 | 0 | 75,0% | 71,4% | 7 | 0 |
| 21. | so 19.02.202219.02. | MFK Tatran Liptovský MikulášLMI | 3:2 | MFK RužomberokRUŽ | 67 | 1 | 0 | 44,4% | 81,3% | 16 | 0 |
| 22. | so 26.02.202226.02. | MFK RužomberokRUŽ | 1:0 |  FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 90 | 0 | 1 | 50,0% | 72,7% | 22 | |
| - 1. | pi 04.03.202204.03. | MFK RužomberokRUŽ | 4:1 | FC DAC 1904 Dunajská StredaDAC | 90 | 1 | 1 | 22,7% | 64,7% | 17 | 0 |
| - 2. | so 12.03.202212.03. | ŠK Slovan Bratislava SLO | 1:1 | MFK RužomberokRUŽ | 90 | 0 | 0 | 33,3% | 78,9% | 19 | 0 |
| - 3. | ne 20.03.202220.03. | MFK RužomberokRUŽ | 0:0 | FC Spartak TrnavaSPA | 90 | 0 | 0 | 51,9% | 63,0% | 27 | 0 |
| - 4. | pi 01.04.202201.04. | MŠK ŽilinaŽIL | 0:2 | MFK RužomberokRUŽ | 68 | 1 | 0 | 52,9% | 53,3% | 15 | 0 |
| - 5. | ne 10.04.202210.04. | ŠKF ORION TIP SereďSER | 1:3 | MFK RužomberokRUŽ | 86 | 1 | 0 | 42,9% | 60,0% | 15 | 0 |
| - 6. | pi 15.04.202215.04. | MFK RužomberokRUŽ | 0:0 | ŠK Slovan Bratislava SLO | 90 | 0 | 0 | 37,5% | 59,1% | 22 | 0 |
| - 7. | ne 24.04.202224.04. | FC Spartak TrnavaSPA | 0:0 | MFK RužomberokRUŽ | 74 | 0 | 0 | 30,0% | 75,0% | 12 | 0 |
