| 2. | so 31.07.202131.07. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 2:0 |  MFK Zemplín MichalovceMIC | 44 | 0 | 0 | 36,4% | 83,3% | 6 | 0 |
| 3. | so 07.08.202107.08. | MFK Zemplín MichalovceMIC | 1:2 |  AS TrenčínTRE | 62 | 1 | 0 | 43,8% | 70,0% | 10 | 0 |
| 4. | so 14.08.202114.08. | ŠK Slovan Bratislava SLO | 3:1 | MFK Zemplín MichalovceMIC | 24 | 0 | 0 | 50,0% | 40,0% | 5 | |
| 5. | so 21.08.202121.08. | MFK Zemplín MichalovceMIC | 2:1 |  MFK Tatran Liptovský MikulášLMI | 90 | 0 | 1 | 35,5% | 70,0% | 20 | |
| 6. | so 28.08.202128.08. | MFK RužomberokRUŽ | 0:0 | MFK Zemplín MichalovceMIC | 57 | 0 | 0 | 20,0% | 44,4% | 9 | 0 |
| 7. | so 11.09.202111.09. | MFK Zemplín MichalovceMIC | 1:2 |  FC Spartak TrnavaSPA | 44 | 0 | 0 | 27,3% | 87,5% | 8 | 0 |
| 8. | so 18.09.202118.09. | MFK Zemplín MichalovceMIC | 2:1 |  FC ViOn Zlaté Moravce - VrábleZMO | 87 | 1 | 0 | 45,0% | 76,5% | 17 | 0 |
| 9. | so 25.09.202125.09. | ŠKF ORION TIP SereďSER | 0:1 | MFK Zemplín MichalovceMIC | 66 | 0 | 0 | 37,0% | 56,3% | 16 | 0 |
| 10. | so 02.10.202102.10. | MFK Zemplín MichalovceMIC | 1:0 |  MŠK ŽilinaMŠK | 58 | 0 | 0 | 48,0% | 78,6% | 14 | 0 |
| 11. | so 16.10.202116.10. | FK SenicaSEN | 1:1 | MFK Zemplín MichalovceMIC | 82 | 0 | 1 | 19,4% | 85,0% | 20 | 0 |
| 12. | ne 24.10.202124.10. | FC DAC 1904 Dunajská StredaDAC | 1:0 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 44,0% | 63,3% | 30 | 0 |
| 13. | so 30.10.202130.10. | MFK Zemplín MichalovceMIC | 0:2 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 90 | 0 | 0 | 40,0% | 63,6% | 22 | 0 |
| 14. | pi 05.11.202105.11. | AS TrenčínTRE | 4:2 | MFK Zemplín MichalovceMIC | 87 | 1 | 0 | 30,0% | 70,0% | 20 | 0 |
| 15. | ne 21.11.202121.11. | MFK Zemplín MichalovceMIC | 1:2 | ŠK Slovan Bratislava SLO | 90 | 1 | 0 | 36,0% | 81,5% | 27 | 0 |
| 16. | so 27.11.202127.11. | MFK Tatran Liptovský MikulášLMI | 0:1 | MFK Zemplín MichalovceMIC | 90 | 1 | 0 | 37,8% | 57,9% | 19 | 0 |
| 17. | so 04.12.202104.12. | MFK Zemplín MichalovceMIC | 0:3 | MFK RužomberokRUŽ | 90 | 0 | 0 | 37,5% | 73,9% | 23 | 0 |
| 18. | pi 10.12.202110.12. | FC Spartak TrnavaSPA | 2:0 | MFK Zemplín MichalovceMIC | 87 | 0 | 0 | 53,3% | 83,3% | 36 | 0 |
| 19. | so 18.12.202118.12. | FC ViOn Zlaté Moravce - VrábleZMO | 0:1 | MFK Zemplín MichalovceMIC | 90 | 1 | 0 | 30,4% | 76,5% | 34 | 0 |
