| 1. | ne 25.07.202125.07. | MŠK ŽilinaMŠK | 3:0 |  ŠKF ORION TIP SereďSER | 90 | 0 | 0 | 50,0% | 85,2% | 27 | |
| 2. | pi 30.07.202130.07. | ŠKF ORION TIP SereďSER | 2:3 |  MFK RužomberokRUŽ | 90 | 0 | 0 | 75,0% | 66,7% | 30 | 0 |
| 3. | ne 08.08.202108.08. | ŠKF ORION TIP SereďSER | 1:0 |  FC DAC 1904 Dunajská StredaDAC | 90 | 0 | 0 | 47,8% | 66,7% | 18 | |
| 4. | so 14.08.202114.08. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 1:1 | ŠKF ORION TIP SereďSER | 90 | 0 | 0 | 35,0% | 55,6% | 27 | 0 |
| 5. | ne 22.08.202122.08. | ŠKF ORION TIP SereďSER | 0:1 |  ŠK Slovan Bratislava SLO | 82 | 0 | 0 | 43,8% | 75,0% | 28 | 0 |
| 6. | so 28.08.202128.08. | AS TrenčínTRE | 0:0 | ŠKF ORION TIP SereďSER | 87 | 0 | 0 | 55,6% | 59,4% | 32 | 0 |
| 7. | so 11.09.202111.09. | ŠKF ORION TIP SereďSER | 2:0 |  MFK Tatran Liptovský MikulášLMI | 82 | 1 | 0 | 40,0% | 85,2% | 27 | 0 |
| 8. | pi 17.09.202117.09. | FC Spartak TrnavaSPA | 2:0 | ŠKF ORION TIP SereďSER | 90 | 0 | 0 | 42,9% | 66,7% | 30 | |
| 9. | so 25.09.202125.09. | ŠKF ORION TIP SereďSER | 0:1 |  MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 43,5% | 78,3% | 23 | 0 |
| 10. | so 02.10.202102.10. | ŠKF ORION TIP SereďSER | 2:1 |  FK SenicaSEN | 44 | 1 | 0 | 27,3% | 81,8% | 22 | 0 |
| 11. | so 16.10.202116.10. | FC ViOn Zlaté Moravce - VrábleZMO | 2:2 | ŠKF ORION TIP SereďSER | 88 | 0 | 0 | 33,3% | 61,1% | 36 | |
| 12. | pi 22.10.202122.10. | ŠKF ORION TIP SereďSER | 1:1 | MŠK ŽilinaMŠK | 72 | 0 | 1 | 28,6% | 76,0% | 25 | |
| 14. | so 06.11.202106.11. | FC DAC 1904 Dunajská StredaDAC | 1:3 | ŠKF ORION TIP SereďSER | 75 | 0 | 0 | 38,5% | 83,3% | 18 | |
| 15. | so 20.11.202120.11. | ŠKF ORION TIP SereďSER | 3:1 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 84 | 0 | 1 | 71,4% | 76,2% | 42 | 0 |
| 16. | po 29.11.202129.11. | ŠK Slovan Bratislava SLO | 2:0 | ŠKF ORION TIP SereďSER | 75 | 0 | 0 | 35,3% | 76,5% | 34 | 0 |
| 17. | so 04.12.202104.12. | ŠKF ORION TIP SereďSER | 4:2 | AS TrenčínTRE | 79 | 2 | 0 | 55,0% | 60,0% | 30 | 0 |
| 18. | so 11.12.202111.12. | MFK Tatran Liptovský MikulášLMI | 1:1 | ŠKF ORION TIP SereďSER | 90 | 0 | 0 | 40,0% | 61,8% | 34 | |
| 19. | so 18.12.202118.12. | ŠKF ORION TIP SereďSER | 0:1 | FC Spartak TrnavaSPA | 90 | 0 | 0 | 57,7% | 58,5% | 53 | |
| 20. | pi 11.02.202211.02. | MFK Zemplín MichalovceMIC | 0:1 | ŠKF ORION TIP SereďSER | 90 | 0 | 0 | 46,2% | 61,1% | 36 | 0 |
| 21. | ne 20.02.202220.02. | FK SenicaSEN | 1:2 | ŠKF ORION TIP SereďSER | 86 | 0 | 0 | 55,6% | 60,0% | 25 | 0 |
| 22. | so 26.02.202226.02. | ŠKF ORION TIP SereďSER | 2:1 | FC ViOn Zlaté Moravce - VrábleZMO | 90 | 0 | 0 | 50,0% | 65,9% | 41 | 0 |
| T6 - 1. | so 05.03.202205.03. | FC Spartak TrnavaSPA | 0:1 | ŠKF ORION TIP SereďSER | 90 | 0 | 0 | 59,1% | 57,7% | 26 | 0 |
| T6 - 2. | so 12.03.202212.03. | ŠKF ORION TIP SereďSER | 1:1 | MŠK ŽilinaMŠK | 90 | 0 | 0 | 55,6% | 54,3% | 35 | 0 |
| T6 - 3. | so 19.03.202219.03. | ŠK Slovan Bratislava SLO | 5:1 | ŠKF ORION TIP SereďSER | 69 | 0 | 0 | 57,1% | 59,1% | 22 | 0 |
| T6 - 4. | so 02.04.202202.04. | FC DAC 1904 Dunajská StredaDAC | 0:0 | ŠKF ORION TIP SereďSER | 44 | 0 | 0 | 35,7% | 68,8% | 16 | 0 |
| T6 - 5. | ne 10.04.202210.04. | ŠKF ORION TIP SereďSER | 1:3 | MFK RužomberokRUŽ | 77 | 0 | 0 | 38,5% | 88,9% | 18 | 0 |
| T6 - 6. | ne 17.04.202217.04. | ŠKF ORION TIP SereďSER | 0:2 | FC Spartak TrnavaSPA | 87 | 0 | 0 | 47,4% | 73,1% | 26 | 0 |
| T6 - 7. | so 23.04.202223.04. | MŠK ŽilinaMŠK | 1:1 | ŠKF ORION TIP SereďSER | 20 | 0 | 0 | 50,0% | 81,3% | 16 | 0 |
| T6 - 8. | so 30.04.202230.04. | ŠKF ORION TIP SereďSER | 0:0 | FC DAC 1904 Dunajská StredaDAC | 46 | 0 | 0 | 36,4% | 58,3% | 12 | 0 |
| T6 - 9. | so 14.05.202214.05. | ŠKF ORION TIP SereďSER | 0:3 | ŠK Slovan Bratislava SLO | 44 | 0 | 0 | 60,0% | 61,1% | 18 | 0 |
| T6 - 10. | so 21.05.202221.05. | MFK RužomberokRUŽ | 3:1 | ŠKF ORION TIP SereďSER | 65 | 0 | 0 | 42,9% | 60,6% | 33 | 0 |
MFK Skalica