| 2. | so 31.07.202131.07. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 2:0 |  MFK Zemplín MichalovceMIC | 90 | 0 | 2 | 2 | 0 |
| 3. | so 07.08.202107.08. | MFK Zemplín MichalovceMIC | 1:2 |  AS TrenčínTRE | 90 | 0 | 2 | 0 | 0 |
| 5. | so 21.08.202121.08. | MFK Zemplín MichalovceMIC | 2:1 |  MFK Tatran Liptovský MikulášLMI | 90 | 0 | 1 | 2 | 0 |
| 6. | so 28.08.202128.08. | MFK RužomberokRUŽ | 0:0 | MFK Zemplín MichalovceMIC | 90 | 1 | 0 | 5 | 0 |
| 7. | so 11.09.202111.09. | MFK Zemplín MichalovceMIC | 1:2 |  FC Spartak TrnavaSPA | 90 | 0 | 2 | 6 | 0 |
| 8. | so 18.09.202118.09. | MFK Zemplín MichalovceMIC | 2:1 |  FC ViOn Zlaté Moravce - VrábleZMO | 90 | 0 | 1 | 2 | 0 |
| 9. | so 25.09.202125.09. | ŠKF ORION TIP SereďSER | 0:1 | MFK Zemplín MichalovceMIC | 90 | 1 | 0 | 6 | |
| 10. | so 02.10.202102.10. | MFK Zemplín MichalovceMIC | 1:0 |  MŠK ŽilinaMŠK | 90 | 1 | 0 | 6 | 0 |
| 11. | so 16.10.202116.10. | FK SenicaSEN | 1:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 1 | 0 | 0 |
| 13. | so 30.10.202130.10. | MFK Zemplín MichalovceMIC | 0:2 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 90 | 0 | 2 | 1 | 0 |
| 15. | ne 21.11.202121.11. | MFK Zemplín MichalovceMIC | 1:2 |  ŠK Slovan Bratislava SLO | 90 | 0 | 2 | 1 | 0 |
| 16. | so 27.11.202127.11. | MFK Tatran Liptovský MikulášLMI | 0:1 | MFK Zemplín MichalovceMIC | 90 | 1 | 0 | 1 | 0 |
| 17. | so 04.12.202104.12. | MFK Zemplín MichalovceMIC | 0:3 | MFK RužomberokRUŽ | 90 | 0 | 3 | 4 | 0 |
| 18. | pi 10.12.202110.12. | FC Spartak TrnavaSPA | 2:0 | MFK Zemplín MichalovceMIC | 90 | 0 | 2 | 2 | 0 |
| 19. | so 18.12.202118.12. | FC ViOn Zlaté Moravce - VrábleZMO | 0:1 | MFK Zemplín MichalovceMIC | 90 | 1 | 0 | 4 | 0 |
| Z - 8. | so 30.04.202230.04. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 1:2 | MFK Zemplín MichalovceMIC | 90 | 0 | 1 | 2 | 0 |
| Z - 9. | pi 13.05.202213.05. | MFK Zemplín MichalovceMIC | 1:2 | MFK Tatran Liptovský MikulášLMI | 90 | 0 | 2 | 2 | 0 |
| Z - 10. | so 21.05.202221.05. | AS TrenčínTRE | 2:2 | MFK Zemplín MichalovceMIC | 1 | 0 | 2 | 0 | 0 |
