| 1. | ne 25.07.202125.07. | MFK Zemplín MichalovceMIC | 4:1 |  FC DAC 1904 Dunajská StredaDAC | 87 | 0 | 1 | 36,0% | 65,7% | 35 | |
| 2. | so 31.07.202131.07. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 2:0 | MFK Zemplín MichalovceMIC | 46 | 0 | 0 | 47,1% | 70,0% | 20 | 0 |
| 3. | so 07.08.202107.08. | MFK Zemplín MichalovceMIC | 1:2 |  AS TrenčínTRE | 28 | 0 | 0 | 87,5% | 76,9% | 13 | 0 |
| 4. | so 14.08.202114.08. | ŠK Slovan Bratislava SLO | 3:1 | MFK Zemplín MichalovceMIC | 18 | 0 | 0 | 20,0% | 100,0% | 4 | 0 |
| 6. | so 28.08.202128.08. | MFK RužomberokRUŽ | 0:0 | MFK Zemplín MichalovceMIC | 9 | 0 | 0 | 100,0% | 90,0% | 10 | 0 |
| 8. | so 18.09.202118.09. | MFK Zemplín MichalovceMIC | 2:1 |  FC ViOn Zlaté Moravce - VrábleZMO | 35 | 0 | 0 | 55,6% | 74,1% | 27 | 0 |
| 9. | so 25.09.202125.09. | ŠKF ORION TIP SereďSER | 0:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 61,5% | 72,2% | 36 | 0 |
| 10. | so 02.10.202102.10. | MFK Zemplín MichalovceMIC | 1:0 |  MŠK ŽilinaMŠK | 90 | 0 | 1 | 64,3% | 60,9% | 46 | 0 |
| 11. | so 16.10.202116.10. | FK SenicaSEN | 1:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 45,2% | 71,7% | 46 | 0 |
| 12. | ne 24.10.202124.10. | FC DAC 1904 Dunajská StredaDAC | 1:0 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 50,0% | 70,6% | 34 | 0 |
| 13. | so 30.10.202130.10. | MFK Zemplín MichalovceMIC | 0:2 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 60 | 0 | 0 | 33,3% | 80,6% | 36 | 0 |
| 14. | pi 05.11.202105.11. | AS TrenčínTRE | 4:2 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 83,3% | 63,6% | 44 | 0 |
| 15. | ne 21.11.202121.11. | MFK Zemplín MichalovceMIC | 1:2 | ŠK Slovan Bratislava SLO | 90 | 0 | 0 | 75,0% | 62,5% | 32 | 0 |
| 16. | so 27.11.202127.11. | MFK Tatran Liptovský MikulášLMI | 0:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 50,0% | 74,4% | 43 | 0 |
| 17. | so 04.12.202104.12. | MFK Zemplín MichalovceMIC | 0:3 | MFK RužomberokRUŽ | 11 | 0 | 0 | 50,0% | 88,9% | 9 | 0 |
| 18. | pi 10.12.202110.12. | FC Spartak TrnavaSPA | 2:0 | MFK Zemplín MichalovceMIC | 3 | 0 | 0 | 0,0% | 0,0% | 0 | 0 |
| 19. | so 18.12.202118.12. | FC ViOn Zlaté Moravce - VrábleZMO | 0:1 | MFK Zemplín MichalovceMIC | 23 | 0 | 0 | 60,0% | 70,6% | 17 | 0 |
| 20. | pi 11.02.202211.02. | MFK Zemplín MichalovceMIC | 0:1 | ŠKF ORION TIP SereďSER | 4 | 0 | 0 | 0,0% | 100,0% | 5 | 0 |
| 21. | so 19.02.202219.02. | MŠK ŽilinaMŠK | 2:1 | MFK Zemplín MichalovceMIC | 18 | 0 | 0 | 66,7% | 50,0% | 10 | 0 |
| 22. | so 26.02.202226.02. | MFK Zemplín MichalovceMIC | 0:1 | FK SenicaSEN | 46 | 0 | 0 | 41,7% | 53,8% | 13 | 0 |
| Z - 3. | so 19.03.202219.03. | MFK Zemplín MichalovceMIC | 1:0 | FC ViOn Zlaté Moravce - VrábleZMO | 6 | 0 | 0 | 0,0% | 66,7% | 3 | 0 |
| Z - 4. | so 02.04.202202.04. | MFK Zemplín MichalovceMIC | 1:0 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 11 | 0 | 0 | 33,3% | 83,3% | 6 | 0 |
| Z - 5. | pi 08.04.202208.04. | MFK Tatran Liptovský MikulášLMI | 3:1 | MFK Zemplín MichalovceMIC | 46 | 0 | 0 | 25,0% | 72,7% | 11 | 0 |
| Z - 6. | po 18.04.202218.04. | FC ViOn Zlaté Moravce - VrábleZMO | 1:1 | MFK Zemplín MichalovceMIC | 24 | 0 | 0 | 57,1% | 62,5% | 8 | 0 |
| Z - 7. | so 23.04.202223.04. | MFK Zemplín MichalovceMIC | 1:0 | FK SenicaSEN | 61 | 0 | 0 | 77,8% | 69,8% | 53 | 0 |
| Z - 10. | so 21.05.202221.05. | AS TrenčínTRE | 2:2 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 52,6% | 77,1% | 35 | 0 |
