| 1. | ne 25.07.202125.07. | MFK Zemplín MichalovceMIC | 4:1 |  FC DAC 1904 Dunajská StredaDAC | 67 | 1 | 1 | 55,0% | 65,0% | 20 | |
| 2. | so 31.07.202131.07. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 2:0 | MFK Zemplín MichalovceMIC | 67 | 0 | 0 | 50,0% | 74,2% | 31 | |
| 3. | so 07.08.202107.08. | MFK Zemplín MichalovceMIC | 1:2 |  AS TrenčínTRE | 76 | 0 | 0 | 54,2% | 73,1% | 26 | 0 |
| 4. | so 14.08.202114.08. | ŠK Slovan Bratislava SLO | 3:1 | MFK Zemplín MichalovceMIC | 72 | 0 | 0 | 66,7% | 81,0% | 21 | 0 |
| 5. | so 21.08.202121.08. | MFK Zemplín MichalovceMIC | 2:1 |  MFK Tatran Liptovský MikulášLMI | 28 | 0 | 0 | 22,2% | 81,8% | 11 | 0 |
| 6. | so 28.08.202128.08. | MFK RužomberokRUŽ | 0:0 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 31,8% | 69,2% | 26 | 0 |
| 7. | so 11.09.202111.09. | MFK Zemplín MichalovceMIC | 1:2 |  FC Spartak TrnavaSPA | 89 | 0 | 0 | 53,6% | 81,8% | 33 | 0 |
| 8. | so 18.09.202118.09. | MFK Zemplín MichalovceMIC | 2:1 |  FC ViOn Zlaté Moravce - VrábleZMO | 35 | 0 | 0 | 75,0% | 80,0% | 15 | 0 |
| 9. | so 25.09.202125.09. | ŠKF ORION TIP SereďSER | 0:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 65,2% | 86,7% | 30 | |
| 10. | so 02.10.202102.10. | MFK Zemplín MichalovceMIC | 1:0 |  MŠK ŽilinaMŠK | 82 | 0 | 0 | 65,5% | 78,1% | 32 | 0 |
| 11. | so 16.10.202116.10. | FK SenicaSEN | 1:1 | MFK Zemplín MichalovceMIC | 75 | 0 | 0 | 55,2% | 83,3% | 36 | |
| 12. | ne 24.10.202124.10. | FC DAC 1904 Dunajská StredaDAC | 1:0 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 68,0% | 84,0% | 25 | |
| 14. | pi 05.11.202105.11. | AS TrenčínTRE | 4:2 | MFK Zemplín MichalovceMIC | 87 | 0 | 0 | 43,8% | 76,7% | 30 | 0 |
| 15. | ne 21.11.202121.11. | MFK Zemplín MichalovceMIC | 1:2 | ŠK Slovan Bratislava SLO | 90 | 0 | 0 | 72,7% | 83,8% | 37 | 0 |
| 16. | so 27.11.202127.11. | MFK Tatran Liptovský MikulášLMI | 0:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 61,5% | 92,2% | 51 | 0 |
| 17. | so 04.12.202104.12. | MFK Zemplín MichalovceMIC | 0:3 | MFK RužomberokRUŽ | 62 | 0 | 0 | 25,0% | 77,8% | 36 | 0 |
| 20. | pi 11.02.202211.02. | MFK Zemplín MichalovceMIC | 0:1 | ŠKF ORION TIP SereďSER | 44 | 0 | 0 | 66,7% | 81,6% | 38 | 0 |
| 21. | so 19.02.202219.02. | MŠK ŽilinaMŠK | 2:1 | MFK Zemplín MichalovceMIC | 72 | 0 | 0 | 64,3% | 87,5% | 24 | 0 |
| 22. | so 26.02.202226.02. | MFK Zemplín MichalovceMIC | 0:1 | FK SenicaSEN | 44 | 0 | 0 | 78,9% | 86,0% | 43 | 0 |
| Z - 1. | so 05.03.202205.03. | MFK Zemplín MichalovceMIC | 1:0 | AS TrenčínTRE | 85 | 0 | 0 | 70,6% | 67,7% | 31 | 0 |
| Z - 2. | so 12.03.202212.03. | FK SenicaSEN | 2:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 62,1% | 78,4% | 37 | 0 |
| Z - 3. | so 19.03.202219.03. | MFK Zemplín MichalovceMIC | 1:0 | FC ViOn Zlaté Moravce - VrábleZMO | 90 | 0 | 0 | 67,9% | 63,0% | 54 | 0 |
| Z - 4. | so 02.04.202202.04. | MFK Zemplín MichalovceMIC | 1:0 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 52 | 0 | 0 | 38,9% | 76,5% | 17 | 0 |
| Z - 6. | po 18.04.202218.04. | FC ViOn Zlaté Moravce - VrábleZMO | 1:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 36,8% | 77,4% | 31 | 0 |
| Z - 7. | so 23.04.202223.04. | MFK Zemplín MichalovceMIC | 1:0 | FK SenicaSEN | 90 | 0 | 0 | 66,7% | 81,5% | 54 | 0 |
| Z - 8. | so 30.04.202230.04. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 1:2 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 40,0% | 74,2% | 31 | |
| Z - 9. | pi 13.05.202213.05. | MFK Zemplín MichalovceMIC | 1:2 | MFK Tatran Liptovský MikulášLMI | 90 | 0 | 0 | 57,1% | 80,4% | 46 | 0 |
| Z - 10. | so 21.05.202221.05. | AS TrenčínTRE | 2:2 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 52,4% | 81,5% | 27 | 0 |
