| 8. | so 18.09.202118.09. | MFK Zemplín MichalovceMIC | 2:1 |  FC ViOn Zlaté Moravce - VrábleZMO | 3 | 0 | 0 | 0,0% | 50,0% | 2 | 0 |
| 10. | so 02.10.202102.10. | MFK Zemplín MichalovceMIC | 1:0 |  MŠK ŽilinaMŠK | 8 | 0 | 0 | 25,0% | 60,0% | 5 | 0 |
| 11. | so 16.10.202116.10. | FK SenicaSEN | 1:1 | MFK Zemplín MichalovceMIC | 82 | 1 | 0 | 46,9% | 65,5% | 29 | 0 |
| 12. | ne 24.10.202124.10. | FC DAC 1904 Dunajská StredaDAC | 1:0 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 35,7% | 68,2% | 22 | |
| 13. | so 30.10.202130.10. | MFK Zemplín MichalovceMIC | 0:2 |  FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 89 | 0 | 0 | 25,0% | 76,9% | 26 | 0 |
| 14. | pi 05.11.202105.11. | AS TrenčínTRE | 4:2 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 38,9% | 50,0% | 20 | 0 |
| 15. | ne 21.11.202121.11. | MFK Zemplín MichalovceMIC | 1:2 |  ŠK Slovan Bratislava SLO | 75 | 0 | 0 | 38,5% | 59,1% | 22 | 0 |
| 16. | so 27.11.202127.11. | MFK Tatran Liptovský MikulášLMI | 0:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 23,8% | 75,0% | 16 | 0 |
| 17. | so 04.12.202104.12. | MFK Zemplín MichalovceMIC | 0:3 |  MFK RužomberokRUŽ | 90 | 0 | 0 | 40,9% | 58,1% | 31 | |
| 18. | pi 10.12.202110.12. | FC Spartak TrnavaSPA | 2:0 | MFK Zemplín MichalovceMIC | 87 | 0 | 0 | 33,3% | 69,4% | 36 | 0 |
| 19. | so 18.12.202118.12. | FC ViOn Zlaté Moravce - VrábleZMO | 0:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 60,9% | 81,3% | 32 | |
| 20. | pi 11.02.202211.02. | MFK Zemplín MichalovceMIC | 0:1 |  ŠKF ORION TIP SereďSER | 86 | 0 | 0 | 61,5% | 64,3% | 28 | 0 |
| 21. | so 19.02.202219.02. | MŠK ŽilinaMŠK | 2:1 | MFK Zemplín MichalovceMIC | 63 | 0 | 0 | 56,3% | 76,0% | 25 | |
| 22. | so 26.02.202226.02. | MFK Zemplín MichalovceMIC | 0:1 | FK SenicaSEN | 77 | 0 | 0 | 29,4% | 70,4% | 27 | 0 |
| Z - 1. | so 05.03.202205.03. | MFK Zemplín MichalovceMIC | 1:0 | AS TrenčínTRE | 90 | 1 | 0 | 55,0% | 61,3% | 31 | 0 |
| Z - 2. | so 12.03.202212.03. | FK SenicaSEN | 2:1 | MFK Zemplín MichalovceMIC | 68 | 0 | 0 | 11,1% | 64,7% | 17 | 0 |
| Z - 3. | so 19.03.202219.03. | MFK Zemplín MichalovceMIC | 1:0 | FC ViOn Zlaté Moravce - VrábleZMO | 90 | 0 | 0 | 50,0% | 68,4% | 38 | 0 |
| Z - 4. | so 02.04.202202.04. | MFK Zemplín MichalovceMIC | 1:0 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 90 | 1 | 0 | 48,3% | 53,8% | 26 | 0 |
| Z - 5. | pi 08.04.202208.04. | MFK Tatran Liptovský MikulášLMI | 3:1 | MFK Zemplín MichalovceMIC | 90 | 0 | 0 | 50,0% | 64,5% | 31 | |
| Z - 7. | so 23.04.202223.04. | MFK Zemplín MichalovceMIC | 1:0 | FK SenicaSEN | 90 | 0 | 0 | 36,4% | 73,1% | 26 | 0 |
| Z - 8. | so 30.04.202230.04. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 1:2 | MFK Zemplín MichalovceMIC | 90 | 1 | 0 | 28,6% | 72,0% | 25 | 0 |
| Z - 9. | pi 13.05.202213.05. | MFK Zemplín MichalovceMIC | 1:2 | MFK Tatran Liptovský MikulášLMI | 90 | 0 | 0 | 23,1% | 82,1% | 28 | 0 |
| Z - 10. | so 21.05.202221.05. | AS TrenčínTRE | 2:2 | MFK Zemplín MichalovceMIC | 90 | 1 | 0 | 44,4% | 81,6% | 38 | 0 |
